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The reverse genetic tactic as well as a tracing experiment working with secure isotope-labeled fatty acids discovered the ELO/DES pathway is the only real DHA synthesis pathway in Parietichytrium sp. Disruption in the C20 fatty acid ELO (C20ELO) and ∆4 fatty acid DES (∆4DES) genes with expression of ωthree fatty acid DES in this thraustochytrid permitted the production of EPA and n-3docosapentaenoic acid (n-3DPA), respectively, at the highest stage among regarded microbial resources employing fed-batch culture.

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A rising overall body of proof has created it achievable to determine the leading role of impaired lipid metabolism in several processes happening within the vascular wall in atherosclerosis (eleven).

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